Claudine Janet Diana Isaacs, MD| Medical Oncology, Breast Medical Oncology | MedStar Health
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Claudine Janet Diana Isaacs

Claudine Janet Diana Isaacs, MD
Provider is directly employed by MedStar Health

4.9 out of 5 (532 reviews)

Specialties: Medical Oncology, Breast Medical Oncology, Cancer Genetics

Languages: English, French

202-444-9429

About me

Dr. Claudine Isaacs is a medical oncologist who specializes in the care of women with all stages of breast cancer. She is Professor of Medicine and Oncology, Associate Director of Clinical Research and Leader of the Clinical Breast Cancer Program at the Georgetown Lombardi Comprehensive Cancer Center. She is also the Medical Director of the Jess and Mildred Fisher Center for Hereditary Cancer and Clinical Genomics Research. She has been practicing for over 20 years.

Dr. Isaacs received her medical degree and internal medicine residency training at McGill University, Canada. She completed fellowship training in the Division of Hematology and Oncology at McGill University and a Fellowship in Breast Medical Oncology in the Division of Medical Oncology at Georgetown University. She then joined the faculty in the Department of Medicine and Oncology at Georgetown University.

Dr. Isaacs has extensive experience in the conduct of clinical trials focusing on all aspects of breast cancer. Additional research interests include cancer risk assessment and medical management and prevention strategies for women at high risk for breast cancer. She has served as the principal investigator of a variety of clinical trials in the treatment of early-stage and metastatic breast cancer, and currently serves as the principal investigator of the Translational Breast Cancer Research Consortium (TBCRC), the ISPY2 trial at Georgetown University. She has authored over 200 peer-reviewed publications. She has also served on a number of committees, including the Cancer Education Committee at the American Society of Clinical Oncology (ASCO), the ASCO Scientific Program Committee, the Breast Oncology Local Diseases Task Force of the Breast Steering Committee of the National Cancer Institute, and most recently the ASCO guidelines committee. She has been named one of America's Top Cancer Doctors by Castle Connolly/Newsweek for many years running, and has also received designations from Washingtonian Magazine and Women's Health Magazine.


Dr. Isaacs' Philosophy of Care:

I strive to personalize the care of my patients by tailoring state-of-the-art therapy to their individual situations and by providing them with access to cutting-edge clinical trials. Equally important is that the care of my patients extends well beyond focusing just on the optimal therapy of their cancer.  My approach to care is to relate to each of my patients as individuals in the context of their lives, and not solely based on the characteristics of their disease. To that end, I work with a wonderful and dedicated multidisciplinary group of expert colleagues who are deeply committed to and involved with our patients' care. The whole team is focused solely on breast cancer and includes medical oncologists, surgeons, radiation oncologists, breast imagers, and pathologists who are supported by an experienced team of clinical nurse coordinators, nurse navigators, research nurses, genetic counselors and social workers, all championing a multidisciplinary approach to breast cancer diagnosis, treatment and recovery. We are not treating a disease. We are treating a person and we are here to provide state-of-the-art medical treatment and to accompany that person navigates their cancer journey.

Clinical areas of focus

  • Cancer Genetics Consultation
  • Family History-Based Cancer Risk Assessment
  • Genetic Testing For Cancer Patients
  • Genetic Testing For Hereditary Cancer
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Procedures I perform

  • A1c Testing
  • Abdominal Wall Biopsy
  • Adjuvant Hormone Therapy
  • Antiangiogenic Therapy
  • Bladder Tumor Prevention
  • Bone Biopsy
  • Brca Gene Testing
  • Breast Biopsy
  • Breast Cancer
  • Breast Cancer And Fertility
  • Breast Cancer Chemoprevention
  • Breast Cancer Pain Management
  • Breast Cancer Screening
  • Breast Cancer Treatment
  • Breast Density Evaluation
  • Breast Infection Treatment
  • Breast Lift Surgery
  • Breast Seroma Aspiration
  • Ca 19-9 Test
  • Cancer Genetics Consultation
  • Cancer Risk Assessment
  • Cea Testing For Colorectal Cancer
  • Chemotherapy Administration
  • Circulating Tumor Cell Monitoring
  • Diagnostic Breast Imaging
  • Diagnostic Mammography
  • Digital Breast Tomosynthesis
  • Ductal Carcinoma In Situ (DCIS) Surgery
  • Family History-Based Cancer Risk Assessment
  • Fine Needle Aspiration Biopsy
  • Fish Testing For Breast Cancer
  • Genetic Counseling
  • Genetic Testing For Cancer Patients
  • Genetic Testing For Down Syndrome
  • Genetic Testing For Hereditary Cancer
  • Genetic Testing For Stargardt Disease
  • Genomic Testing For Cancer
  • High-Risk Breast Lesion Management
  • Hormone Replacement Therapy
  • Immunotherapy
  • Introduction Of Antineoplastic
  • Liquid Biopsy
  • Liver Biopsy
  • Lymph Node Biopsy
  • Lynch Syndrome Testing
  • Mammaprint Testing
  • Modified Radical Mastectomy
  • Pathology Consultation
  • Preventive Medicine Counseling
  • Prophylactic Oophorectomy
  • Psa Testing
  • Risk-Reducing Mastectomy
  • Risk-Reducing Salpingo-Oophorectomy
  • Selective Estrogen Receptor Modulator (SERM) Therapy
  • Targeted Genome Sequencing
  • Tumor Immunohistochemistry
  • Tumor Marker Testing
  • Ultrasound
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Practice locations

Distance from Change LocationEnter your Location

3800 Reservoir Rd NW
Lombardi Cancer Center
Washington, DC, 20007

202-444-2223

Fax 202-444-1229

Get Directions

miles away

Fax 202-444-1229

Insurance

MedStar Health accepts most major health insurance plans. If you are uncertain as to whether your individual health insurance plan is accepted at MedStar Health, please call your insurance company.

  • List of insurance plans we accept
    • Aetna Worker's Compensation Network
    • HumanaChoice Honor's plan PPO
    • HUMANA/Choice Care Medicare Plans (Choice, Gold Choice)
    • Johns Hopkins Advantage MD HMO
    • Anthem BCBS of VA HealthKeepers (HMO)
    • Cigna Achieve Medicare (HMO C-SNP)
    • Coventry of Delaware HMO/PPO
    • Aetna Managed Choice Open Access (POS)
    • Navigate
    • United Healthcare Choice Plus
    • United Student Resources
    • UHC Passport
    • UnitedHealthcare Medicare Adv. Special Needs Plans
    • CareFirst FEP Blue Focus
    • CIGNA SureFit (HMO)
    • Aetna Classic 3500
    • Aetna Advantage 5750
    • Aetna Elect Choice/ EPO (Aetna Health Fund)
    • HighMark
    • CareFirst Blue Card Program
    • Kaiser Permanente Signature - Added Choice
    • Kaiser Permanente Select Cardiac Global
    • POS OA
    • Employee Health Plan
    • Cigna True Choice Medicare (PPO)
    • Aetna VA Exchange
    • IH-Network Only Plus
    • CareFirst Blue Choice Opt Out Open Access
    • Humana Medicare Advantage - PPO
    • Kaiser Permanente Flexible Choice POS Cardiac Global
    • IH-Open HMO
    • HealthyBlue PPO
    • TRICARE for Life East
    • Amerigroup DC Alliance
    • United Healthcare Community Plan - VA Medicaid MCO
    • TRICARE East Prime
    • United Healthcare Choice
    • Medicare Advantage - Advantra Value (PPO)
    • CIGNA EPO
    • IH-Open POS II
    • Anthem BCBS Medi Blue Plus
    • CareFirst Maryland Indemnity or PPO
    • IH-POS Plus
    • Blue Choice Advantage
    • Alterwood Advanatge HMO & DSNP Plans
    • IH-Indemnity
    • Aetna Better Health of MD
    • Anthem Federal Employee Program Basic
    • CIGNA HMO Open Access
    • Humana Gold Plus HMO
    • IH-PPO
    • UnitedHealthcare Individual Exchange Plans
    • Kaiser Permanente HMO Plus and DHMO Plus Member
    • Mamsi Life & Health (Indem./PPO) Cardiac Global
    • AmeriHealth Caritas DC Healthy Families
    • Optima Family Care MCO - VA Medicaid MCO
    • United Healthcare Select HMO-EPO/NPP Cardiac Global
    • NYC Medicare Advantage Plus
    • Aetna Advantage 6350
    • Aetna Traditional Choice (PPO)
    • Lasso Healthcare - Medicare Medical Savings Account
    • DC/MD SHOP QHP Small Business Plans
    • Tricare Reserve Select
    • Medicare Direct
    • IH-Open POS Plus
    • Optimum Choice
    • Choice POS II
    • Cigna True Choice Plus Medicare (PPO)
    • IH-Open Network Only Plus
    • CareFirst Group Medicare Advantage
    • Cigna Preferred Medicare (HMO)
    • First Health PPO
    • Options PPO Cardiac Global
    • Anthem BCBS of VA HealthKeepers Plus
    • Anthem Federal Employee Program Standard
    • United Healthcare Select Plus (POS)
    • AMERIVANTAGE/Amerigroup Community Care
    • Network OA
    • Great-West Healthcare POS/CIGNA
    • UnitedHealthcare Medicare Advantage DSNP District of Columbia
    • Aetna Student Health Insurance
    • CareFirst (NCA) Indemnity
    • Kaiser Permanente Medicare Plus
    • IH-Open EPO Plus
    • CIGNA POS/Network POS
    • CIGNA PPO
    • Veterans Affairs Community Care Network
    • CareFirst Community Health Plan of MD
    • OA Plus
    • Humana Medicare Advantage - HMO Open Access
    • CareFirst BlueChoice HMO
    • CareFirst Blue Choice Opt Out Plus Open Access (POS)
    • WellPoint Maryland - Maryland Health Choice
    • Mamsi Life & Health (Indem./PPO)
    • Private Health Care Systems (PPO)
    • Beech Street PPO
    • Johns Hopkins Advantage MD PLUS PPO
    • Anthem BCBS of VA HealthKeepers (POS & POS OA)
    • Kaiser Permanente Flexible Choice 3-tier POS
    • Maryland Physicians Care MCO
    • Aetna Advantage 6350PD
    • Cigna Alliance Medicare (HMO)
    • Priority Partners - Maryland Health Choice
    • United Healthcare Choice Plus Cardiac Global
    • Anthem BCBS Medi Blue Dual Adv
    • CareFirst MedStar PPO
    • United Medicare Private Fee-for-Service (PFFS) plans
    • Select HMO/HealthFund/Health Network
    • HumanaChoice PPO
    • Magellan Complete Care of VA - VA Medicaid MCO
    • Kaiser Permaenete Signature - Added Choice Cardiac Global
    • Aetna Classic 5000PD
    • UHC Group Medicare Advantage Plans (HMO, POS, PPO)
    • CIGNA HMO & Network (HMO)
    • Aetna Open Choice (PPO)
    • Kaiser Permanente Medicare Advantage Signature and Select
    • CareFirst Maryland Point of Service Plan
    • Choice Care Network/HUMANA (PPO)
    • M.D. IPA Preferred (POS)
    • United Healthcare Navigate Cardiac Global
    • Aetna HMO
    • Anthem BCBS of VA Key Care POS/PPO/Indemnity
    • CareFirst Dual Prime HMO-SNP
    • Optimum Choice Preferred (POS)
    • Erickson Advantage Plans
    • Choice POS
    • Kaiser Permanente Select - Added Choice
    • TriWest Healthcare Alliance
    • Amerigroup DC Healthy Families
    • Healthy Blue (HMO, POS)
    • CIGNA Indemnity
    • MedStar Family Choice DC Healthy Families
    • CIGNA PPO Plus
    • Health Services for Children with Special Needs
    • First Health PPO
    • Kaiser Maryland Medicaid MCO
    • CareFirst EPO
    • CareFirst NASCO
    • CareFirst BlueCross BlueShield Advantage Core/Enhanced
    • TRICARE East Select
    • OCI Direct (HMO)
    • United HealthCare Community Plan - Maryland Health Choice Program
    • Uniformed Services Family Health Plan
    • Fee-for-Service (FFS) District of Columbia, Maryland and Virginia Medicaid
    • Aetna Signature Administrator PPO/TPA
    • CareFirst MedStar Select PPO
    • CareFirst Federal Employee Program (Std. & Basic PPO)
    • Jai Medical Systems - Maryland Health Choice
    • Johns Hopkins Advantage MD PPO
    • MedStar Family Choice - Maryland Health Choice
    • BCBS of Michigan (BCN Advantage,Security Blue, Freedom, Medicare PLUS Blue Group PPO)
    • Aetna Better Health of VA
    • United Healthcare Options (PPO)
    • Medicare FFS
    • Optimum Choice & Optimum Choice Preferred (POS) Cardiac Global
    • Aetna Elect Choice/ Open Access (POS)
    • Private Fee-for-Service Plans (PFFS)
    • Kaiser Permanente Signature
    • Core Essential (HMO)
    • Aetna Managed Choice (POS)
    • Aetna Medicare Advantage HMO & PPO Plans
    • MD IPA (HMO) & MD IPA Preferred Cardiac Global
    • Choice POS II Open Access
    • Aetna Premier 200PD
    • Aetna Basic
    • IH-EPO Plus
    • Aetna Medicare Advantage PFFS Plan
    • IH-HMO
    • CareFirst Administrators
    • Kaiser Permanente Select
    • Police and Fire Clinic
    • CareFirst Blue Preferred PPO
    • Coventry Health Care of Virginia
    • Sentara Health
    • UnitedHealthcare and AARP Medicare Complete Plans
    • IH-POS
    • Anthem BCBS Medi Blue SNP
    • M.D. IPA (HMO)
    • Geisinger Medicare Advantage
    • AmeriHealth Caritas DC Healthcare Alliance
    • MedStar Family Choice DC Healthcare Alliance
    • IH-Open HMO Option
    • Aetna Quality Point of Service (POS)
    • Choice Fund PPO
    • Coventry Health Care National Network PPO
    • MultiPlan, Inc
    • Advantra Platinum (PPO)
    • Aetna HMO-Open Access/Select OA/HealthFund/Health Network Option OA
    • United Healthcare Choice Cardiac Global
    • United Healthcare Select HMO - EPO/NPP
    • Cigna TotalCare (HMO D-SNP)
    • BCBS Out-of-State Medicare Plans (Blue Advantage)
    • Aetna Classic 5000
    • CareFirst Group Medicare Advantage prescription drug benefit (PPO)
    • CIGNA Connect EPO
    • BlueChoice Open Access

Videos

Education

Board Certification: American Board of Internal Medicine, Medical Oncology/Medical Oncology

Fellowship: Georgetown University School of Medicine GME (1993)

Fellowship: McGill University (1992)

Residency: McGill University Faculty of Medicine (1990)

Internship: Montreal General Hospital (1988)

Medical School: McGill University (1987)

Awards

  • Washingtonian Top Doc 2025 America’s Top Doctors for Women, Women’s Health Magazine
  • Marquis Who’s Who in America            
  • America’s Top Doctors, Castle Connolly
  • Newsweek’s Top Cancer Doctors
  • Top Doctors Washington DC, Washingtonian Magazine
  • Global Directory Top Doctors
  • Global Directory of Who’s Who
  • Top Doctors Washington DC Area, Northern Virginia Magazine
  • Estelle Ramey Mentorship Award, Georgetown University School of Medicine

Ratings and reviews

  • Explanations the care provider gave you about your problem or condition

    4.9
  • Extent to which the care provider listened to you

    4.9
  • Care provider’s discussion of any proposed treatment (options, risks, benefits, etc.)

    4.9
  • Provider included you in decisions

    4.9
  • Concern the care provider showed for your questions or worries

    4.9
  • Likelihood of recommending this care provider to others

    4.9
  • Apr 18, 2026

    Dr Isaacs is a compassionate, thoughtful and supportive professional practitioner who uses her expertise with confident ease

  • Jan 15, 2026

    Dr Issacs is excellent

  • Dec 18, 2025

    Dr Claudine Isaacs is outstanding