Claudine Janet Diana Isaacs, MD| Medical Oncology, Cancer Genetics | MedStar Health
Claudine Janet Diana Isaacs

Claudine Janet Diana Isaacs, MD
Provider is directly employed by MedStar Health

4.9 out of 5 (511 reviews)

Specialties: Medical Oncology, Cancer Genetics, Breast Medical Oncology

Languages: English, French

202-444-9429

About me

Dr. Claudine Isaacs is a medical oncologist who specializes in the care of women with all stages of breast cancer. She is Professor of Medicine and Oncology, Associate Director of Clinical Research and Leader of the Clinical Breast Cancer Program at the Georgetown Lombardi Comprehensive Cancer Center. She is also the Medical Director of the Jess and Mildred Fisher Center for Hereditary Cancer and Clinical Genomics Research. She has been practicing for over 20 years.

Dr. Isaacs received her medical degree and internal medicine residency training at McGill University, Canada. She completed fellowship training in the Division of Hematology and Oncology at McGill University and a Fellowship in Breast Medical Oncology in the Division of Medical Oncology at Georgetown University. She then joined the faculty in the Department of Medicine and Oncology at Georgetown University.

Dr. Isaacs has extensive experience in the conduct of clinical trials focusing on all aspects of breast cancer. Additional research interests include cancer risk assessment and medical management and prevention strategies for women at high risk for breast cancer. She has served as the principal investigator of a variety of clinical trials in the treatment of early-stage and metastatic breast cancer, and currently serves as the principal investigator of the Translational Breast Cancer Research Consortium (TBCRC), the ISPY2 trial at Georgetown University. She has authored over 200 peer-reviewed publications. She has also served on a number of committees, including the Cancer Education Committee at the American Society of Clinical Oncology (ASCO), the ASCO Scientific Program Committee, the Breast Oncology Local Diseases Task Force of the Breast Steering Committee of the National Cancer Institute, and most recently the ASCO guidelines committee. She has been named one of America's Top Cancer Doctors by Castle Connolly/Newsweek for many years running, and has also received designations from Washingtonian Magazine and Women's Health Magazine.


Dr. Isaacs' Philosophy of Care:

I strive to personalize the care of my patients by tailoring state-of-the-art therapy to their individual situations and by providing them with access to cutting-edge clinical trials. Equally important is that the care of my patients extends well beyond focusing just on the optimal therapy of their cancer.  My approach to care is to relate to each of my patients as individuals in the context of their lives, and not solely based on the characteristics of their disease. To that end, I work with a wonderful and dedicated multidisciplinary group of expert colleagues who are deeply committed to and involved with our patients' care. The whole team is focused solely on breast cancer and includes medical oncologists, surgeons, radiation oncologists, breast imagers, and pathologists who are supported by an experienced team of clinical nurse coordinators, nurse navigators, research nurses, genetic counselors and social workers, all championing a multidisciplinary approach to breast cancer diagnosis, treatment and recovery. We are not treating a disease. We are treating a person and we are here to provide state-of-the-art medical treatment and to accompany that person navigates their cancer journey.

Clinical areas of focus

  • Cancer Genetics Consultation
  • Family History-Based Cancer Risk Assessment
  • Genetic Testing For Cancer Patients
  • Genetic Testing For Hereditary Cancer
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Procedures I perform

  • A1c Testing
  • Abdominal Wall Biopsy
  • Adjuvant Hormone Therapy
  • Antiangiogenic Therapy
  • Bladder Tumor Prevention
  • Bone Biopsy
  • Brca Gene Testing
  • Breast Biopsy
  • Breast Cancer
  • Breast Cancer And Fertility
  • Breast Cancer Chemoprevention
  • Breast Cancer Pain Management
  • Breast Cancer Screening
  • Breast Cancer Treatment
  • Breast Density Evaluation
  • Breast Infection Treatment
  • Breast Lift Surgery
  • Breast Seroma Aspiration
  • Ca 19-9 Test
  • Cancer Genetics Consultation
  • Cancer Risk Assessment
  • Cea Testing For Colorectal Cancer
  • Chemotherapy Administration
  • Circulating Tumor Cell Monitoring
  • Diagnostic Breast Imaging
  • Diagnostic Mammography
  • Digital Breast Tomosynthesis
  • Ductal Carcinoma In Situ (DCIS) Surgery
  • Family History-Based Cancer Risk Assessment
  • Fine Needle Aspiration Biopsy
  • Fish Testing For Breast Cancer
  • Genetic Counseling
  • Genetic Testing For Cancer Patients
  • Genetic Testing For Down Syndrome
  • Genetic Testing For Hereditary Cancer
  • Genetic Testing For Stargardt Disease
  • Genomic Testing For Cancer
  • High-Risk Breast Lesion Management
  • Hormone Replacement Therapy
  • Immunotherapy
  • Introduction Of Antineoplastic
  • Liquid Biopsy
  • Liver Biopsy
  • Lymph Node Biopsy
  • Lynch Syndrome Testing
  • Mammaprint Testing
  • Modified Radical Mastectomy
  • Pathology Consultation
  • Preventive Medicine Counseling
  • Prophylactic Oophorectomy
  • Psa Testing
  • Risk-Reducing Mastectomy
  • Risk-Reducing Salpingo-Oophorectomy
  • Selective Estrogen Receptor Modulator (SERM) Therapy
  • Targeted Genome Sequencing
  • Tumor Immunohistochemistry
  • Tumor Marker Testing
  • Ultrasound
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Practice locations

Distance from Change LocationEnter your Location

3800 Reservoir Rd NW
Lombardi Cancer Center
Washington, DC, 20007

202-444-2223

Fax 202-444-1229

Get Directions

miles away

Fax 202-444-1229

Insurance

MedStar Health accepts most major health insurance plans. If you are uncertain as to whether your individual health insurance plan is accepted at MedStar Health, please call your insurance company.

  • List of insurance plans we accept
    • Amerigroup DC Healthy Families
    • Healthy Blue (HMO, POS)
    • IH-Open Network Only Plus
    • CareFirst Group Medicare Advantage prescription drug benefit (PPO)
    • Choice POS II
    • Kaiser Permanente Signature - Added Choice
    • IH-Open POS II
    • United Healthcare Select Plus (POS)
    • AMERIVANTAGE/Amerigroup Community Care
    • Anthem BCBS Medi Blue Plus
    • Great-West Healthcare POS/CIGNA
    • Geisinger Medicare Advantage
    • CareFirst MedStar Select PPO
    • Medicare FFS
    • Sentara Health
    • Coventry of Delaware HMO/PPO
    • Employee Health Plan
    • Anthem BCBS Medi Blue Dual Adv
    • CIGNA HMO & Network (HMO)
    • Cigna Achieve Medicare (HMO C-SNP)
    • Options PPO Cardiac Global
    • IH-Open EPO Plus
    • Advantra Platinum (PPO)
    • BCBS Out-of-State Medicare Plans (Blue Advantage)
    • Aetna Classic 5000PD
    • CareFirst BlueCross BlueShield Advantage Core/Enhanced
    • United Medicare Private Fee-for-Service (PFFS) plans
    • BCBS of Michigan (BCN Advantage,Security Blue, Freedom, Medicare PLUS Blue Group PPO)
    • CIGNA Connect EPO
    • United Healthcare Choice Plus
    • Aetna HMO-Open Access/Select OA/HealthFund/Health Network Option OA
    • CIGNA PPO
    • Fee-for-Service (FFS) District of Columbia, Maryland and Virginia Medicaid
    • IH-EPO Plus
    • Cigna Preferred Medicare (HMO)
    • Humana Medicare Advantage - HMO Open Access
    • Kaiser Permanente Flexible Choice 3-tier POS
    • Private Fee-for-Service Plans (PFFS)
    • WellPoint Maryland - Maryland Health Choice
    • Aetna Medicare Advantage PFFS Plan
    • Kaiser Permanente Select - Added Choice
    • UnitedHealthcare Medicare Advantage DSNP District of Columbia
    • HUMANA/Choice Care Medicare Plans (Choice, Gold Choice)
    • CIGNA SureFit (HMO)
    • Kaiser Permanente Select Cardiac Global
    • Aetna Classic 3500
    • United Healthcare Options (PPO)
    • UHC Passport
    • Anthem BCBS of VA HealthKeepers (HMO)
    • United Healthcare Select HMO-EPO/NPP Cardiac Global
    • Anthem BCBS Medi Blue SNP
    • Cigna TotalCare (HMO D-SNP)
    • Aetna Advantage 6350PD
    • Aetna Student Health Insurance
    • Cigna True Choice Medicare (PPO)
    • MD IPA (HMO) & MD IPA Preferred Cardiac Global
    • Aetna Better Health of MD
    • HighMark
    • MedStar Family Choice DC Healthy Families
    • United HealthCare Community Plan - Maryland Health Choice Program
    • Anthem BCBS of VA HealthKeepers Plus
    • BlueChoice Open Access
    • CareFirst Administrators
    • TriWest Healthcare Alliance
    • Kaiser Permanente Medicare Advantage Signature and Select
    • CareFirst Community Health Plan of MD
    • Priority Partners - Maryland Health Choice
    • CareFirst NASCO
    • IH-Open HMO Option
    • Coventry Health Care of Virginia
    • United Healthcare Select HMO - EPO/NPP
    • United Healthcare Community Plan - VA Medicaid MCO
    • CIGNA PPO Plus
    • Aetna Basic
    • United Healthcare Choice Plus Cardiac Global
    • Choice POS
    • Humana Gold Plus HMO
    • IH-Open HMO
    • IH-POS
    • IH-HMO
    • Kaiser Permanente Select
    • United Healthcare Navigate Cardiac Global
    • Beech Street PPO
    • NYC Medicare Advantage Plus
    • Navigate
    • TRICARE for Life East
    • Police and Fire Clinic
    • CareFirst Blue Preferred PPO
    • Aetna Traditional Choice (PPO)
    • Anthem BCBS of VA HealthKeepers (POS & POS OA)
    • Optimum Choice & Optimum Choice Preferred (POS) Cardiac Global
    • Choice Fund PPO
    • UnitedHealthcare and AARP Medicare Complete Plans
    • CareFirst Dual Prime HMO-SNP
    • Coventry Health Care National Network PPO
    • Health Services for Children with Special Needs
    • AmeriHealth Caritas DC Healthy Families
    • CareFirst Maryland Indemnity or PPO
    • CareFirst Group Medicare Advantage
    • CareFirst Blue Choice Opt Out Plus Open Access (POS)
    • MultiPlan, Inc
    • Optima Family Care MCO - VA Medicaid MCO
    • DC/MD SHOP QHP Small Business Plans
    • M.D. IPA Preferred (POS)
    • Aetna Better Health of VA
    • CareFirst Maryland Point of Service Plan
    • Alterwood Advanatge HMO & DSNP Plans
    • Aetna Open Choice (PPO)
    • Jai Medical Systems - Maryland Health Choice
    • UnitedHealthcare Medicare Adv. Special Needs Plans
    • United Healthcare Choice
    • Johns Hopkins Advantage MD HMO
    • Lasso Healthcare - Medicare Medical Savings Account
    • Aetna Managed Choice (POS)
    • Aetna Quality Point of Service (POS)
    • Johns Hopkins Advantage MD PPO
    • Maryland Physicians Care MCO
    • CareFirst Federal Employee Program (Std. & Basic PPO)
    • IH-Indemnity
    • CIGNA POS/Network POS
    • Network OA
    • TRICARE East Prime
    • CIGNA HMO Open Access
    • Tricare Reserve Select
    • Aetna Elect Choice/ Open Access (POS)
    • CareFirst BlueChoice HMO
    • CareFirst Blue Card Program
    • Aetna Medicare Advantage HMO & PPO Plans
    • Private Health Care Systems (PPO)
    • Aetna Advantage 5750
    • Amerigroup DC Alliance
    • Optimum Choice
    • First Health PPO
    • Kaiser Permanente HMO Plus and DHMO Plus Member
    • Erickson Advantage Plans
    • UHC Group Medicare Advantage Plans (HMO, POS, PPO)
    • Cigna Alliance Medicare (HMO)
    • Select HMO/HealthFund/Health Network
    • United Healthcare Choice Cardiac Global
    • CIGNA Indemnity
    • Johns Hopkins Advantage MD PLUS PPO
    • MedStar Family Choice - Maryland Health Choice
    • Aetna Classic 5000
    • Aetna VA Exchange
    • Humana Medicare Advantage - PPO
    • Choice POS II Open Access
    • Magellan Complete Care of VA - VA Medicaid MCO
    • Anthem Federal Employee Program Basic
    • Choice Care Network/HUMANA (PPO)
    • CareFirst Blue Choice Opt Out Open Access
    • HealthyBlue PPO
    • Anthem BCBS of VA Key Care POS/PPO/Indemnity
    • Kaiser Permaenete Signature - Added Choice Cardiac Global
    • Kaiser Maryland Medicaid MCO
    • HumanaChoice Honor's plan PPO
    • IH-Network Only Plus
    • IH-POS Plus
    • Kaiser Permanente Flexible Choice POS Cardiac Global
    • HumanaChoice PPO
    • Veterans Affairs Community Care Network
    • Mamsi Life & Health (Indem./PPO) Cardiac Global
    • Medicare Advantage - Advantra Value (PPO)
    • Medicare Direct
    • Cigna True Choice Plus Medicare (PPO)
    • POS OA
    • M.D. IPA (HMO)
    • Aetna Premier 200PD
    • MedStar Family Choice DC Healthcare Alliance
    • CareFirst MedStar PPO
    • Mamsi Life & Health (Indem./PPO)
    • Aetna Managed Choice Open Access (POS)
    • First Health PPO
    • CIGNA EPO
    • Kaiser Permanente Medicare Plus
    • OCI Direct (HMO)
    • Core Essential (HMO)
    • IH-Open POS Plus
    • Aetna Advantage 6350
    • Aetna Worker's Compensation Network
    • United Student Resources
    • Aetna HMO
    • Anthem Federal Employee Program Standard
    • UnitedHealthcare Individual Exchange Plans
    • OA Plus
    • Aetna Signature Administrator PPO/TPA
    • Optimum Choice Preferred (POS)
    • AmeriHealth Caritas DC Healthcare Alliance
    • CareFirst EPO
    • Kaiser Permanente Signature
    • IH-PPO
    • CareFirst (NCA) Indemnity
    • Aetna Elect Choice/ EPO (Aetna Health Fund)
    • Uniformed Services Family Health Plan
    • Blue Choice Advantage
    • CareFirst FEP Blue Focus
    • TRICARE East Select

Videos

Education

Board Certification: American Board of Internal Medicine, Medical Oncology

Fellowship: Georgetown University School of Medicine GME (1993)

Fellowship: McGill University (1992)

Residency: McGill University Faculty of Medicine (1990)

Internship: Montreal General Hospital (1988)

Medical School: McGill University (1987)

Awards

  • Washingtonian Top Doc 2025 America’s Top Doctors for Women, Women’s Health Magazine
  • Marquis Who’s Who in America            
  • America’s Top Doctors, Castle Connolly
  • Newsweek’s Top Cancer Doctors
  • Top Doctors Washington DC, Washingtonian Magazine
  • Global Directory Top Doctors
  • Global Directory of Who’s Who
  • Top Doctors Washington DC Area, Northern Virginia Magazine
  • Estelle Ramey Mentorship Award, Georgetown University School of Medicine

Ratings and reviews

  • Explanations the care provider gave you about your problem or condition

    4.9
  • Extent to which the care provider listened to you

    4.9
  • Care provider’s discussion of any proposed treatment (options, risks, benefits, etc.)

    4.9
  • Provider included you in decisions

    4.9
  • Concern the care provider showed for your questions or worries

    4.9
  • Likelihood of recommending this care provider to others

    4.9
  • Dec 18, 2025

    Dr Claudine Isaacs is outstanding

  • Nov 10, 2025

    Dr. Isaacs is the best!

  • Oct 28, 2025

    Outstanding