Claudine Janet Diana Isaacs, MD| Medical Oncology, Breast Medical Oncology | MedStar Health
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Claudine Janet Diana Isaacs

Claudine Janet Diana Isaacs, MD
Provider is directly employed by MedStar Health

4.9 out of 5 (541 reviews)

Specialties: Medical Oncology, Breast Medical Oncology

Languages: French, English

202-444-9429

About me

Dr. Claudine Isaacs is a medical oncologist who specializes in the care of women with all stages of breast cancer. She is Professor of Medicine and Oncology, Associate Director of Clinical Research and Leader of the Clinical Breast Cancer Program at the Georgetown Lombardi Comprehensive Cancer Center. She is also the Medical Director of the Jess and Mildred Fisher Center for Hereditary Cancer and Clinical Genomics Research. She has been practicing for over 20 years.

Dr. Isaacs received her medical degree and internal medicine residency training at McGill University, Canada. She completed fellowship training in the Division of Hematology and Oncology at McGill University and a Fellowship in Breast Medical Oncology in the Division of Medical Oncology at Georgetown University. She then joined the faculty in the Department of Medicine and Oncology at Georgetown University.

Dr. Isaacs has extensive experience in the conduct of clinical trials focusing on all aspects of breast cancer. Additional research interests include cancer risk assessment and medical management and prevention strategies for women at high risk for breast cancer. She has served as the principal investigator of a variety of clinical trials in the treatment of early-stage and metastatic breast cancer, and currently serves as the principal investigator of the Translational Breast Cancer Research Consortium (TBCRC), the ISPY2 trial at Georgetown University. She has authored over 200 peer-reviewed publications. She has also served on a number of committees, including the Cancer Education Committee at the American Society of Clinical Oncology (ASCO), the ASCO Scientific Program Committee, the Breast Oncology Local Diseases Task Force of the Breast Steering Committee of the National Cancer Institute, and most recently the ASCO guidelines committee. She has been named one of America's Top Cancer Doctors by Castle Connolly/Newsweek for many years running, and has also received designations from Washingtonian Magazine and Women's Health Magazine.


Dr. Isaacs' Philosophy of Care:

I strive to personalize the care of my patients by tailoring state-of-the-art therapy to their individual situations and by providing them with access to cutting-edge clinical trials. Equally important is that the care of my patients extends well beyond focusing just on the optimal therapy of their cancer.  My approach to care is to relate to each of my patients as individuals in the context of their lives, and not solely based on the characteristics of their disease. To that end, I work with a wonderful and dedicated multidisciplinary group of expert colleagues who are deeply committed to and involved with our patients' care. The whole team is focused solely on breast cancer and includes medical oncologists, surgeons, radiation oncologists, breast imagers, and pathologists who are supported by an experienced team of clinical nurse coordinators, nurse navigators, research nurses, genetic counselors and social workers, all championing a multidisciplinary approach to breast cancer diagnosis, treatment and recovery. We are not treating a disease. We are treating a person and we are here to provide state-of-the-art medical treatment and to accompany that person navigates their cancer journey.

Conditions and procedures

Conditions I treat

  • Breast Cancer In Young Women
  • Breast Cancer Metastasis
  • Breast Cancer Recurrence
  • Breast Cancer With Lymph Node Involvement
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Procedures I perform

  • Adjuvant Hormone Therapy
  • Brca Gene Testing
  • Breast Cancer
  • Breast Cancer And Fertility
  • Breast Cancer Treatment
  • Chemotherapy Administration
  • Circulating Tumor Cell Monitoring
  • Genetic Testing For Cancer Patients
  • Genomic Testing For Cancer
  • Immunotherapy
  • Introduction Of Antineoplastic
  • Selective Estrogen Receptor Modulator (SERM) Therapy
  • Targeted Genome Sequencing
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Practice locations

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3800 Reservoir Rd NW
Lombardi Cancer Center
Washington, DC, 20007

202-444-2223
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miles away

Fax 202-444-1229

Insurance

This list represents the major payors accepted by MedStar Health.

NOTE: Payor contracts change and not all plans associated with a payor may be covered. Payors may offer multiple plans. If you have a question related to your insurance, please contact your insurance plan directly. Contact information is located on your health insurance ID card.

*Denotes limited participation. Specific providers and practices may NOT be participating. Please contact your insurance plan directly.

  • List of insurance plans we accept
    • Aetna
    • CareFirst BlueCross BlueShield of Maryland
    • Cigna Health Care
    • Kaiser Permanente*
    • MedStar Select (Administered by CareFirst)
    • United HealthCare
    • Aetna
    • CareFirst BlueCross BlueShield of Maryland
    • Healthspring
    • Humana
    • Medicare & Railroad Medicare
    • United HealthCare
    • Aetna Better Health of Maryland *
    • Medical Assistance/Medicaid
    • MedStar Family Choice MD
    • Priority Partners *
    • United HealthCare Community Health Plan MD
    • Wellpoint MD
    • AmeriHealth Caritas
    • Health Services For Children With Special Needs (HSCSN)
    • Medical Assistance/Medicaid
    • MedStar Family Choice DC
    • Johns Hopkins Employer Health Programs *
    • Johns Hopkins US Family Health Plan *
    • MultiPlan
    • Private Healthcare Systems
    • Tricare/Humana Military
    • VA Community Care Network (VACCN)
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  • Education

    Board Certification: American Board of Internal Medicine, Medical Oncology/Medical Oncology

    Fellowship: Georgetown University School of Medicine GME (1993)

    Fellowship: McGill University (1992)

    Residency: McGill University Faculty of Medicine (1990)

    Internship: Montreal General Hospital (1988)

    Medical School: McGill University (1987)

    Awards

    • Washingtonian Top Doc 2025 America’s Top Doctors for Women, Women’s Health Magazine
    • Marquis Who’s Who in America            
    • America’s Top Doctors, Castle Connolly
    • Newsweek’s Top Cancer Doctors
    • Top Doctors Washington DC, Washingtonian Magazine
    • Global Directory Top Doctors
    • Global Directory of Who’s Who
    • Top Doctors Washington DC Area, Northern Virginia Magazine
    • Estelle Ramey Mentorship Award, Georgetown University School of Medicine

    Ratings and reviews

    • Explanations the care provider gave you about your problem or condition

      4.9
    • Extent to which the care provider listened to you

      4.9
    • Care provider’s discussion of any proposed treatment (options, risks, benefits, etc.)

      4.9
    • Provider included you in decisions

      4.9
    • Concern the care provider showed for your questions or worries

      4.9
    • Likelihood of recommending this care provider to others

      4.9
    • Jun 25, 2026

      I understand what's going on. Expectations laid out clearly and follow-up plan in place.

    • May 26, 2026

      Dr. Isaacs is amazing. She gives me excellent advice, time, expertise, and care. I trust her implicitly.

    • May 22, 2026

      Excellent doctor and person. I really appreciated very much her care and concerns throughout these five years of cancer treatment.